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The severity of SCA3 correlates with the age of onset. It has been found that the earlier the onset, the more severe the disease. Symptoms may begin as early as adolescence and as late as about 70 years of age. SCA3 is a progressive disease, meaning that symptoms get worse with time. Therefore, life expectancy ranges from the mid-thirties for those with severe forms of SCA3 to a normal life expectancy for those with milder forms. Aspiration pneumonia is often the cause of death for those who die early from the disease.
Though there is no cure for SCA3, there are possible treatments for various symptoms. For those who experience parkinsonian features, levodopa therapy can help for many years and spasticity can be reduced with antispasmodic drugs, such as baclofen. Botox® injections have been used to treat various forms of dystonia, such as blepharospasms. Physiotherapy can help with disability associated with gait problems. Physical aids, such as walkers and wheelchairs, can assist the patient with mobility problems . Other problems, such as sleep disturbances, cramps, and urinary dysfunction, can be treated with medications and medical care. Exercise can also be helpful. Although it will not stop the disease from progressing, it can improve muscle strength, balance, bowel function, and bone strength. That, in turn, can help a person with SCA3 feel better, stay in shape, and keep up with as many daily activities as possible. |
